Head and neck cancer (HNC), which includes lip and oral cavity, larynx, nasopharynx,
oropharynx, and hypopharynx malignancies, is one of the most common cancers worldwide …

As an interesting cancer immunotherapy approach, cancer vaccines have been developed
to deliver tumor antigens and adjuvants to antigen-presenting cells (APCs). Although the …

Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …

Oncolytic virotherapy has currently emerged as a powerful therapeutic approach in cancer
treatment. Although the history of using viruses goes back to the early 20th century, the …

Simple Summary Oncolytic virotherapy (OVT) is a promising approach in cancer
immunotherapy. Oncolytic viruses (OVs) could be applied in cancer immunotherapy without …

Evasion of growth suppression is among the prominent hallmarks of cancer. Phosphatase
and tensin homolog (PTEN) and p53 tumor-suppressive pathways are compromised in most …

The incidence of hematological malignancies such as multiple myeloma, leukemia, and
lymphoma has increased over time. Although bone marrow transplantation, immunotherapy …

Despite being a new promising tool for cancer therapy, intravenous delivery of oncolytic
viruses (OVs) is greatly limited by poor tumor targeting, rapid clearance in the blood, severe …

Chimeric antigen receptor T-cell (CAR-T) is particularly prominent in hematological but not
in solid tumors, mainly based on the complex tumor immune microenvironment. Oncolytic …

Abstract Oncolytic adenoviruses (OAds), engineered Ads preferentially infect and lyse tumor
cells, have attracted remarkable attention as immunotherapy weapons for the treatment of …