The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

The human body is a highly aerobic organism, in which it is necessary to match oxygen
supply at tissue levels to the metabolic demands. Along metazoan evolution, an exquisite …

Over the last few years, cancer immunotherapy experienced tremendous developments and
it is nowadays considered a promising strategy against many types of cancer. However, the …

Although critical for brain function, the physiological values of cerebral oxygen concentration
have remained elusive because high-resolution measurements have only been performed …

The brain's endocannabinoid system is a powerful controller of neurotransmitter release,
shaping synaptic communication under physiological and pathological conditions. However …

Seizures are often followed by sensory, cognitive or motor impairments during the postictal
phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that …

Ortiz-Prado, Esteban, Raul Patricio Fernandez Naranjo, Eduardo Vasconez, Katherine
Simbaña-Rivera, Trigomar Correa-Sancho, Alex Lister, Manuel Calvopiña, and Ginés …

Epilepsy is commonly associated with a number of neurodegenerative and pathological
alterations in those areas of the brain that are involved in repeated electrographic seizures …

During transient brain activation cerebral blood flow (CBF) increases substantially more than
cerebral metabolic rate of oxygen consumption (CMRO2) resulting in blood …

Background Multiple studies have attempted to elucidate the relationship between chronic
hypoxia and SARS-CoV-2 infection. It seems that high-altitude is associated with lower …