Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Personalized medicine (personalized psychiatry in a specific setting) is a new model
towards individualized care, in which knowledge from genomics and other omic pillars …

A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …

Complex diseases are defined to be determined by multiple genetic and environmental
factors alone as well as in interactions. To analyze interactions in genetic data, many …

The primary objective of this review is to give an overview of the main findings of the
European multicenter project “Patterns of Treatment Resistance and Switching Strategies in …

For over a decade, the European Group for the Study of Resistant Depression (GSRD) has
examined single nucleotide polymorphisms (SNP) and clinical parameters in regard to …

Major depressive disorder (MDD) is a heritable disease with a heavy personal and socio-
economic burden. Antidepressants of different classes are prescribed to treat MDD, but …

Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …

Up to 60% of depressed patients do not respond completely to antidepressants (ADs) and
up to 30% do not respond at all. Genetic factors contribute for about 50% of the AD …

Adverse events, response failures and medication non-compliance are common in patients
receiving medications for the treatment of mental illnesses. A systematic literature review …