Obesity is the most common cause of insulin resistance, and the current obesity epidemic is
driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic …

Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Examination of cognition has historically been approached from language and introspection.
However, human language–dependent definitions ignore the evolutionary roots of brain …

Accumulated preclinical literature demonstrates that hypothalamic inflammation and gliosis
are underlying causal components of diet-induced obesity in rodent models. This review …

The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known
for its involvement in glucose sensing and whole-body glucose homeostasis. However, it is …

Objective The hypothalamus is the main integrator of peripheral and central signals in the
control of energy homeostasis. Its functional relevance for the effectivity of bariatric surgery is …

While pancreatic β and α cells are considered the main drivers of blood glucose
homeostasis through insulin and glucagon secretion, the contribution of δ cells and …

OBJECTIVE Preclinical research implicates hypothalamic glial cell responses in the
pathogenesis of obesity and type 2 diabetes (T2D). In the current study we sought to …

In experimental models, hypothalamic dysfunction is a key component of the
pathophysiology of diet-induced obesity. Early after the introduction of a high-fat diet …

Environmental and genetic factors cause defects in pancreatic islets driving type 2 diabetes
(T2D) together with the progression of multi-tissue insulin resistance. Mass spectrometry …