Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …
promise in the rapidly expanding pharmaceutical market due to their high specificity and …
Nanoparticle entry into cells; the cell biology weak link
G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
[HTML][HTML] Surface design of nanocarriers: Key to more efficient oral drug delivery systems
H Spleis, M Sandmeier, V Claus… - Advances in Colloid and …, 2023 - Elsevier
As nanocarriers (NCs) can improve the solubility of drugs, prevent their degradation by
gastrointestinal (GI) enzymes and promote their transport across the mucus gel layer and …
gastrointestinal (GI) enzymes and promote their transport across the mucus gel layer and …
Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: Drug delivery and beyond
F Topuz, T Uyar - Carbohydrate Polymers, 2022 - Elsevier
Nanogels/microgels are swollen cross-linked polymer networks with tunable
physicochemical properties and are commonly employed for the effective delivery of …
physicochemical properties and are commonly employed for the effective delivery of …
[HTML][HTML] Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications
Q Guan, GB Wang, LL Zhou, WY Li, YB Dong - Nanoscale Advances, 2020 - pubs.rsc.org
Cancer nanomedicine is one of the most promising domains that has emerged in the
continuing search for cancer diagnosis and treatment. The rapid development of …
continuing search for cancer diagnosis and treatment. The rapid development of …
Extracellular vesicles for improved tumor accumulation and penetration
N Bie, T Yong, Z Wei, L Gan, X Yang - Advanced drug delivery reviews, 2022 - Elsevier
Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …
Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety …
L Zhang, F He, L Gao, M Cong, J Sun, J Xu… - International Journal …, 2021 - Taylor & Francis
Background Exosomes are a type of membrane vesicles secreted by living cells. Recent
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …
[HTML][HTML] Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …
How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects
J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …
Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles
E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …