Nanocarrier‐mediated cytosolic delivery of biopharmaceuticals

W He, X Xing, X Wang, D Wu, W Wu… - Advanced functional …, 2020 - Wiley Online Library
Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Nanoparticle entry into cells; the cell biology weak link

G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …

[HTML][HTML] Surface design of nanocarriers: Key to more efficient oral drug delivery systems

H Spleis, M Sandmeier, V Claus… - Advances in Colloid and …, 2023 - Elsevier
As nanocarriers (NCs) can improve the solubility of drugs, prevent their degradation by
gastrointestinal (GI) enzymes and promote their transport across the mucus gel layer and …

Advances in the development of cyclodextrin-based nanogels/microgels for biomedical applications: Drug delivery and beyond

F Topuz, T Uyar - Carbohydrate Polymers, 2022 - Elsevier
Nanogels/microgels are swollen cross-linked polymer networks with tunable
physicochemical properties and are commonly employed for the effective delivery of …

[HTML][HTML] Nanoscale covalent organic frameworks as theranostic platforms for oncotherapy: synthesis, functionalization, and applications

Q Guan, GB Wang, LL Zhou, WY Li, YB Dong - Nanoscale Advances, 2020 - pubs.rsc.org
Cancer nanomedicine is one of the most promising domains that has emerged in the
continuing search for cancer diagnosis and treatment. The rapid development of …

Extracellular vesicles for improved tumor accumulation and penetration

N Bie, T Yong, Z Wei, L Gan, X Yang - Advanced drug delivery reviews, 2022 - Elsevier
Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …

Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety …

L Zhang, F He, L Gao, M Cong, J Sun, J Xu… - International Journal …, 2021 - Taylor & Francis
Background Exosomes are a type of membrane vesicles secreted by living cells. Recent
studies suggest exosome-like nanovesicles (ELNVs) from fruits and vegetables are involved …

[HTML][HTML] Nanoparticle–cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy

X Li, B Dai, J Guo, L Zheng, Q Guo, J Peng, J Xu… - Nano-micro letters, 2021 - Springer
Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …

How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehicles

E Xu, WM Saltzman, AS Piotrowski-Daspit - Journal of Controlled Release, 2021 - Elsevier
Non-viral vehicles hold therapeutic promise in advancing the delivery of a variety of cargos
in vitro and in vivo, including small molecule drugs, biologics, and especially nucleic acids …