Poorly regulated reward seeking is a central feature of substance use disorder. Recent
research shows that rewarding drug-related experiences induce synchronous activation of a …

Abstract Δ9-tetrahydrocannabinol (THC) is the intoxicating constituent of cannabis and is
responsible for the drug's reinforcing effects. Retrospective human studies suggest that …

In individuals with substance use disorders, stress is a critical determinant of relapse
susceptibility. In some cases, stressors directly trigger cocaine use. In others, stressors …

Although there is a sex bias in the pathological mechanisms exhibited by brain disorders,
investigation of the female brain in biomedical science has long been neglected. Use of the …

Addiction is a chronic relapsing disorder, and during recovery many people experience
several relapse events as they attempt to voluntarily abstain from drug. New preclinical …

(1) Background: Adiponectin is an adipocyte-secreted hormone that has antidepressant-and
anxiolytic-like effects in preclinical studies. Here, we investigated the antidepressant-and …

Opioid-alcohol polysubstance use is prevalent and worsens treatment outcomes. Here we
assessed whether co-consumption of oxycodone and alcohol influence the intake of one …

Corticotropin releasing factor (CRF) is a key component of stress responsivity, modulating
related behaviors including anxiety and reward. Difficulties identifying CRF neurons, using …

Positive social relationships are paramount for the survival of mammals and beneficial for
mental and physical health, buffer against stressors, and even promote appropriate immune …

Peripheral inputs continuously shape brain function and can influence memory acquisition,
but the underlying mechanisms have not been fully understood. Cannabinoid type-1 …