A white paper on phospholipid hydroperoxide glutathione peroxidase (GPx4) forty years later

F Ursini, VB Travain, G Cozza, G Miotto… - Free Radical Biology …, 2022 - Elsevier
The purification of a protein inhibiting lipid peroxidation led to the discovery of the
selenoperoxidase GPx4 forty years ago. Thus, the evidence of the enzymatic activity was …

Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology

V Zara, G Assalve, A Ferramosca - Cellular and Molecular Life Sciences, 2022 - Springer
The citrate carrier (CIC) is an integral protein of the inner mitochondrial membrane which
catalyzes the efflux of mitochondrial citrate (or other tricarboxylates) in exchange with a …

Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

E Radaelli, CA Assenmacher, J Verrelle, E Banerjee… - Elife, 2023 - elifesciences.org
Impaired spermatogenesis and male infertility are common manifestations associated with
mitochondrial diseases, yet the underlying mechanisms linking these conditions remain …

Cryopreservation induces acetylation of metabolism-related proteins in boar sperm

MA Ali, Z Qin, S Dou, A Huang, Y Wang… - International Journal of …, 2023 - mdpi.com
Cryodamage affects the normal physiological functions and survivability of boar sperm
during cryopreservation. Lysine acetylation is thought to be an important regulatory …

Functions and mechanism of noncoding RNA in regulation and differentiation of male mammalian reproduction

D Hashemi Karoii, H Azizi - Cell Biochemistry and Function, 2023 - Wiley Online Library
Noncoding RNAs (ncRNAs) are active regulators of a wide range of biological and
physiological processes, including the majority of mammalian reproductive events …

Impacts of disinfection byproduct exposures on male reproductive health: Current evidence, possible mechanisms and future needs

M Zhang, YL Deng, C Liu, WQ Lu, Q Zeng - Chemosphere, 2023 - Elsevier
Disinfection byproducts (DBPs) are a class of ubiquitous chemicals in drinking water and
inevitably result in widespread human exposures. Potentially adverse health effects of DBP …

A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells

R Zhang, YX Tu, D Ye, Z Gu, ZX Chen… - Advanced …, 2022 - Wiley Online Library
Maintenance and differentiation of germline stem and progenitor cells (GSPCs) is important
for sexual reproduction. Here, the authors identify zebrafish pld6 as a novel germline …

Condensed mitochondria assemble into the acrosomal matrix during spermiogenesis

M Ren, Y Xu, CKL Phoon… - Frontiers in Cell and …, 2022 - frontiersin.org
Mammalian spermatogenesis is associated with the transient appearance of condensed
mitochondria, a singularity of germ cells with unknown function. Using proteomic analysis …

The relationship between sperm nuclear DNA fragmentation, mitochondrial DNA fragmentation, and copy number in normal and abnormal human ejaculates

A Tímermans, F Otero, M Garrido, J Gosálvez… - …, 2024 - Wiley Online Library
Background While it is common to clinically evaluate sperm nuclear DNA fragmentation, less
attention has been given to sperm mitochondrial DNA. Recently, a digital PCR assay has …

Mechanistic Insights into 1, 2-bis (2, 4, 6-tribromophenoxy) ethane-Induced Male Reproductive Toxicity in Zebrafish

N Zheng, X Wang, Y Zhang, J Hua, B Zhu… - Environmental …, 2024 - ACS Publications
The novel brominated flame retardant, 1, 2-bis (2, 4, 6-tribromophenoxy) ethane (BTBPE),
has increasingly been detected in environmental and biota samples. However, limited …