The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

Evolution in the field of the total synthesis of natural products has led to exciting
developments over the last decade. Numerous chemoselective and enantioselective …

Die direkte Funktionalisierung von C‐H‐Bindungen in organischen Molekülen hat sich in
jüngster Zeit zu einer wirksamen und idealen Methode entwickelt, mit der Kohlenstoff …

Acetylcholinesterase (AChE) enzymes play an essential role in the development of
Alzheimer's disease (AD). Its excessive activity causes several neuronal problems …

Abstract Auf dem Gebiet der Totalsynthese von Naturstoffen hat es in den vergangenen
zehn Jahren hochinteressante Entwicklungen gegeben. Zahlreiche chemoselektive und …

The alkaloids characteristically produced by the subfamily Amaryllidoideae of the
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …

Although C–H oxidation of hydrocarbons is generally difficult, allylic C–H oxidation is
relatively simple and predictable, even on a preparative scale, because active species …

The biosynthesis of thebaine is based on the regioselective, intramolecular, oxidative
coupling of (R)‐reticuline. For decades, chemists have sought to mimic this coupling by …

Suzuki coupling of 7 to 8 gave the biphenyl derivative 9. Reaction of 9 with ethyl vinyl
ether/bromine/base gave 10, which on treatment with CsF/DMF at 130° C resulted in the …

A synthesis of the natural product thebaine is reported in eight steps from commercially
available starting materials, hinging on the dearomatization and coupling of simple aromatic …