Updates in diagnosing polycystic ovary syndrome-related infertility

H Haddad-Filho, JAG Tosatti, FM Vale… - Expert Review of …, 2023 - Taylor & Francis
Introduction Polycystic ovary syndrome (PCOS) is a condition that affects approximately 13%
of reproductive age women and is characterized by androgen excess, menstrual irregularity …

[HTML][HTML] Future potential of in vitro maturation including fertility preservation

J Cadenas, L la Cour Poulsen, LS Mamsen… - Fertility and …, 2023 - Elsevier
In several mammalian species, oocytes from small antral follicles after in vitro maturation
(IVM) are successfully used for procreation. Humans are the exception, mainly because of …

[HTML][HTML] Concentrations of oocyte secreted GDF9 and BMP15 decrease with MII transition during human IVM

J Cadenas, SE Pors, A Kumar, B Kalra… - Reproductive Biology …, 2022 - Springer
Background The suggested effects of the oocyte secreted GDF9 and BMP15 growth factors
on oocyte maturation are currently based on recombinant proteins, and little is known about …

Regulation of human oocyte maturation in vivo during the final maturation of follicles

J Cadenas, LC Poulsen, D Nikiforov… - Human …, 2023 - academic.oup.com
STUDY QUESTION Which substances and signal transduction pathways are potentially
active downstream to the effect of FSH and LH in the regulation of human oocyte maturation …

[HTML][HTML] Effects of hypoxia-preconditioned HucMSCs on neovascularization and follicle survival in frozen/thawed human ovarian cortex transplanted to …

J Cheng, X Ruan, Y Li, J Du, F Jin, M Gu… - Stem Cell Research & …, 2022 - Springer
Background The massive loss of follicles in the early stage of ovarian tissue transplantation
is considered a significant restriction to the efficacy of ovarian tissue cryopreservation (OTC) …

Eight weeks of androgen priming by daily low-dose hCG injections before ICSI treatment in women with low ovarian reserve

N Friis Wang, JW Bogstad, SE Pors… - Human …, 2023 - academic.oup.com
STUDY QUESTION Does 8 weeks of continuous low-dose hCG administration increase the
proportion of antral follicles that reach the preovulatory state during ovarian stimulation (OS) …

Biochanin-A attenuates DHEA-induced polycystic ovary syndrome via upregulation of GDF9 and BMP15 signaling in vivo

RSS Kotipalli, SS Patnaik, JM Kumar, S Ramakrishna… - Life Sciences, 2023 - Elsevier
Aims Phytoestrogens can act as natural estrogens owing to their structural similarity to
human estrogens. Biochanin-A (BCA) is a well-studied phytoestrogen with a wide variety of …

A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human

Y Liu, H Fan, X Kang, Y Hao, N Wang… - Proceedings of the …, 2024 - National Acad Sciences
Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ
cells that mainly occur during the first 30 y of a female's life. Early age of onset strongly …

[HTML][HTML] Application of specific ELISAs for BMP15 and GDF9 to cumulus cell extracts from infertile women

AE Krysta-Matter, AH Riepsamen, S Lien… - Molecular and Cellular …, 2023 - Elsevier
Abstract Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9)
are oocyte-specific paracrine factors which regulate ovarian cumulus cell (CC) functions …

Oxytocin enhances progesterone production with upregulation of BMP-15 activity by granulosa cells

K Yamamoto, Y Nakano, N Iwata, Y Soejima… - Biochemical and …, 2023 - Elsevier
To elucidate the reproductive role of oxytocin (OXT) in ovarian steroidogenesis and its
functional interaction with bone morphogenetic proteins (BMPs), the effects of OXT on …