[HTML][HTML] Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways

V Suryadevara, R Ramchandran, DW Kamp… - International Journal of …, 2020 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …

[HTML][HTML] The role of sphingolipid signaling in oxidative lung injury and pathogenesis of bronchopulmonary dysplasia

JM Thomas, T Sudhadevi, P Basa, AW Ha… - International journal of …, 2022 - mdpi.com
Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Multiomics Reveals Induction of Neuroblastoma SK-N-BE (2) C Cell Death by Mitochondrial Division Inhibitor 1 through Multiple Effects

WH Wang, YC Kao, CH Hsieh, SY Tsai… - Journal of Proteome …, 2023 - ACS Publications
Mitochondrial division inhibitor 1 (Mdivi-1) is a well-known synthetic compound aimed at
inhibiting dynamin-related protein 1 (Drp1) to suppress mitochondrial fission, making it a …

Association between plasma lysophosphatidic acid levels and bronchopulmonary dysplasia in extremely preterm infants: A prospective study

H Li, Z Huang, C Yang, D Han, X Wang… - Pediatric …, 2023 - Wiley Online Library
Background Lysophosphatidic acid (LPA) is implicated in bronchopulmonary dysplasia
(BPD) pathogenesis, but clinical evidence is lacking. This study aimed to investigate LPA …

Hyperoxia-induced S1P1 signaling reduced angiogenesis by suppression of TIE-2 leading to experimental bronchopulmonary dysplasia

T Sudhadevi, A Jafri, AW Ha, P Basa… - Cell biochemistry and …, 2021 - Springer
Introduction We have earlier shown that hyperoxia (HO)-induced sphingosine kinase 1
(SPHK1)/sphingosine-1-phosphate (S1P) signaling contribute to bronchopulmonary …

Knockdown of miR-203a-3p alleviates the development of bronchopulmonary dysplasia partly via the up-regulation of vascular endothelial growth factor A

H Cheng, L Chen, Y Wei, T Hu, D Li, B Wu - Journal of Bioenergetics and …, 2021 - Springer
Bronchopulmonary dysplasia (BPD) is characterized by impaired vascular and alveolar
development, and the underlying molecular mechanisms have remained elusive …

Crystal structures of human serum albumin in complex with lysophosphatidylcholine

Y Wang, Z Luo, X Morelli, P Xu, L Jiang, X Shi… - Biophysical …, 2023 - cell.com
Lysophospholipids (lysoPLs) are crucial metabolites involved in various physiological and
pathological cellular processes. Understanding their binding interactions, particularly with …

Lpar1-mediated Effects in Endothelial Progenitor Cells Are Crucial for Lung Repair in Acute Respiratory Distress Syndrome/Acute Lung Injury

N Li, X Xu, Z Qi, C Gao, P Zhao, J Yang… - American Journal of …, 2023 - atsjournals.org
Acute respiratory distress syndrome/acute lung injury (ARDS/ALI) involves acute respiratory
failure characterized by vascular endothelial and lung alveolar epithelial injury. Endothelial …