Pain is highly prevalent in patients with pancreas cancer and contributes to the morbidity of
the disease. Pain may be due to pancreatic enzyme insufficiency, obstruction, and/or a direct …

In this review, the state of the art for compounds affecting the endocannabinoid (eCB)
system is described with a focus on the treatment of pain. Amongst directly acting CB …

Background The past two decades have seen an increase in cannabis use due to both
regulatory changes and an interest in potential therapeutic effects of the substance, yet …

Aims Opioid misuse and overuse have contributed to a widespread overdose crisis and
many patients and physicians are considering medical cannabis to support opioid tapering …

Background Accumulating evidence has indicated that cannabis substitution is often used
as a harm reduction strategy among people who use unregulated opioids (PWUO) and …

Purpose: Opioid use rates have dropped as North American patients gain access to medical
cannabis, indicating a harm reduction role, yet health outcomes remain mostly unexplored …

Abstract Background and Aims Ecological studies have suggested that Cannabis
legalization might have led to a decrease in opioid overdose deaths. Such studies do not …

A growing body of research has reported on the potential opioid-sparing effects of cannabis
and cannabinoids, but less is known about specific mechanisms. The present research …

Despite high rates of cannabis use during medication-based treatment of opioid use
disorder (MOUD), uncertainty remains around how cannabis influences treatment outcomes …

Background OxyContin was delisted from Canadian provincial drug formularies in March
2012 and replaced with a reformulated tamper-resistant form of oxycodone (ie, OxyNeo). We …