The defense against infectious diseases, either through natural immunity or after
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …

Mitochondrial dysfunction is a hallmark of aging that contributes to inflammaging. It is
characterized by alterations of the mitochondrial DNA, reduced respiratory capacity …

It has been reported that accumulation of senescent cells in various tissues contributes to
pathological aging and that elimination of senescent cells (senolysis) improves age …

Cancer is an age-related disease, with the majority of patients receiving their diagnosis after
the age of 60 and most mortality from cancer occurring after this age. The tumor …

Chronic systemic inflammation is one of the hallmarks of the aging immune system. Here we
show that activated T cells from older adults contribute to inflammaging by releasing …

Immunosenescence refers to the multifaceted and profound alterations in the immune
system brought about by aging, exerting complex influences on the pathophysiological …

With a rapidly aging global population and improvement of outcomes with newer multiple
sclerosis (MS)-specific disease-modifying therapies (DMTs), the epidemiology of MS has …

In mammals, the most remarkable T cell variations with aging are the shrinking of the naïve T
cell pool and the enlargement of the memory T cell pool, which are partially caused by …

Disease-modifying therapies (DMT) administered to patients with multiple sclerosis (MS) can
influence immune responses to SARS-CoV-2 and vaccine efficacy. However, data on the …

Increasing evidence suggests that immunometabolism has started to unveil the role of
metabolism in shaping immune function and autoimmune diseases. In this study, our data …