Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Investigations on the impact of chemicals on the environment and human health have led to
the development of an exposome concept. The exposome refers to the totality of exposures …

Lung cancer is a leading cause of cancer mortality with an inter-individual difference in
susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA …

Air pollution represents a considerable threat to health worldwide. The São Paulo
Metropolitan area, in Brazil, has a unique composition of atmospheric pollutants with a …

Global genome repair (GGR), a subpathway of nucleotide excision repair, corrects bulky
helix-distorting DNA lesions across the whole genome and is essential for preventing …

Individuals differ widely in their ability to repair DNA damage, and DNA‐repair deficiency
may be involved in modulating cancer risk. In a case‐control study of 124 bladder‐cancer …

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high
carcinogenic potencies that have been linked to the etiology of human cancers through their …

Associations between lung cancer risk and common polymorphisms in the DNA repair
genes xeroderma pigmentosum complementation group D (XPD), X-ray repair cross …

This study correlated the extent of induced in vitro chromosomal damage, assessed by the
mutagen sensitivity assay, with genotypes of the X-ray repair cross complementing group 1 …