After more than two decades of preclinical and clinical studies, on August 27, 2019, the US
Food and Drug Administration (FDA) approved the adenosine A 2A receptor antagonist …

The involvement of extracellular nucleotides and adenosine in an array of cell-specific
responses has long been known and appreciated, but the integrative view of purinergic …

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …

The discovery that half of the mammalian protein-coding genome is regulated by the
circadian clock has clear implications for medicine. Recent studies demonstrated that the …

Physicians diagnose and administer treatment as needed; time of day is rarely considered.
Yet, accumulating evidence shows that our molecular clocks orchestrate 24-hour circadian …

Caffeine is a common substance in the diets of most athletes and it is now appearing in
many new products, including energy drinks, sport gels, alcoholic beverages and diet aids. It …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human
physiology. Due to the widespread expression of adenosine receptors, it has far-reaching …

Objectives: This study aimed to investigate the impact of ticagrelor on adenosine plasma
concentration (APC) in acute coronary syndrome (ACS) patients. Background: Ticagrelor is …

The human SLC29 family of proteins contains four members, designated equilibrative
nucleoside transporters (ENTs) because of the properties of the first-characterised family …