Since a first version of this article on the relevance of quasispecies to viral disease control
was published by one of us [1], an explosion of information on viral quasispecies has been …

Hundreds of structures of type 1 human immunodeficiency virus (HIV-1) reverse
transcriptase (RT) have been determined, but only one contains an RNA/DNA hybrid. Here …

A virtual screening protocol has been applied to seek non-nucleoside inhibitors of HIV-1
reverse transcriptase (NNRTIs) and its K103N mutant. First, a chemical similarity search on …

The interactions and energetics associated with the binding of 20 HEPT and 20 nevirapine
nonnucleoside inhibitors of HIV-1 reverse transcriptase (RT) have been explored in an effort …

There is an urgent need for the design and development of new and safer drugs for the
treatment of human immunodeficiency virus (HIV) infection, specifically active against drug …

Like thymidylate synthase (TS) in eukaryotes, the thymidylate synthase-complementing
proteins (TSCPs) are mandatory for cell survival of many prokaryotes in the absence of …

We have determined the crystal structure of the HIV type 1 reverse transcriptase complexed
with CP-94,707, a new nonnucleoside reverse transcriptase inhibitor (NNRTI), to 2.8-Å …

A novel series of substituted N-(2-(2, 3-dioxoindolin-1-yl) acetyl)-2-oxo-1, 2, 3, 4-
tetrahydropyrimidine-5-carboxamide was designed, synthesized and evaluated for in vitro …

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination
therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV …

Polycitone A, an aromatic alkaloid isolated from the ascidian Polycitor sp. exhibits potent
inhibitory capacity of both RNA-and DNA-directed DNA polymerases. The drug inhibits …