The first intron of FTO contains common single nucleotide polymorphisms associated with
body weight and adiposity in humans. In an effort to identify the molecular basis for this …

Genetic association mapping produces statistical links between phenotypes and genomic
regions, but identifying causal variants remains difficult. Whole-genome sequencing (WGS) …

Metabolic syndrome (MetS) has become a health and financial burden worldwide. The MetS
definition captures clustering of risk factors that predict higher risk for diabetes mellitus and …

Although hundreds of genome-wide association studies-implicated loci have been reported
for adult obesity-related traits, less is known about the genetics specific for early-onset …

Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and …

In the 21st century, obesity has become a serious problem because of increasing obese
patients and numerous metabolic complications. The primary reasons for this situation are …

To uncover novel significant association signals (p< 5× 10− 8), genome-wide association
studies (GWAS) requires increasingly larger sample sizes to overcome statistical correction …

Background: Genome-wide association studies (GWAS) have identified consistent
associations with obesity. However, the mechanisms remain unclear. Objective: The …

Background Several studies have identified multiple obesity-associated loci mainly in
European populations. However, their contribution to obesity in other ethnicities such as …

Background The Mexican population and others with Amerindian heritage exhibit a
substantial predisposition to dyslipidemias and coronary heart disease. Yet, these …