Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

Temporomandibular joint (TMJ), a site that is often impacted by osteoarthritis (OA), is
biomechanically linked with dental occlusion. Tissue responses in TMJ condyle to …

Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …

Articular cartilage (AC) is a highly organized connective tissue lining, covering the ends of
bones within articulating joints. Its highly ordered structure is essential for stable motion and …

CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous
advantages such as precisely targeting/shearing ability, low cost and convenient operation …

Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an
overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …

Connexons form the basis of hemichannels and gap junctions. They are composed of six
tetraspan proteins called connexins. Connexons can function as individual hemichannels …