Urotensin II (UII) is an 11 amino acid cyclic peptide originally isolated from the goby fish. The
amino acid sequence of UII is exceptionally conserved across most vertebrate taxa, sharing …

Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost
fish on the basis of its ability to contract the hindgut. Subsequently, UII was characterized in …

Metabolic syndrome (MetS) is a complex disorder characterized by abdominal obesity,
elevated blood pressure, hyperlipidemia, and elevated fasting blood glucose levels. The …

Sepsis is a life-threatening organ dysfunction condition response resulting in acute lung
injury. Urotensin II (UII), an endogenous vasoactive peptide, is widely distributed in …

Somatostatin and its related peptides (SSRPs) form an important family of hormones with
diverse physiological roles. The ubiquitous presence of SSRPs in vertebrates and several …

We have discovered two related chemical series of nonpeptide urotensin-II (U-II) receptor
antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) …

Accumulated evidence shows that elevated urotensin II (UII) levels are associated with
cardiovascular diseases. However, the role of UII in the initiation, progression, and …

Insulin resistance may become the most powerful predictor of future development of type 2
diabetes mellitus (T2DM) and a therapeutic target for the treatment of the same. Both …

Human urotensin II (U-II), the most potent vasoconstrictor undecapeptide identified to date,
and its receptor (UT) are involved in the pathogenesis of systemic and pulmonary …

Objective Diabetic nephropathy is the most common cause of end stage renal failure. Early
treatment of diabetic nephropathy depends on understanding the underlying mechanisms of …