Metal–organic frameworks and their composites for chronic wound healing: from bench to bedside

Y Xiong, Q Feng, L Lu, X Qiu, S Knoedler… - Advanced …, 2024 - Wiley Online Library
Chronic wounds are characterized by delayed and dysregulated healing processes. As
such, they have emerged as an increasingly significant threat. The associated morbidity and …

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

W Xu, Y Wu, W Gu, D Du, Y Lin, C Zhu - Chemical Society Reviews, 2024 - pubs.rsc.org
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential
life transformations. Nevertheless, enzymes only operate under mild conditions to keep …

An immunomodulatory hydrogel by hyperthermia‐assisted self‐cascade glucose depletion and ROS scavenging for diabetic foot ulcer wound therapeutics

X Qi, E Cai, Y Xiang, C Zhang, XX Ge… - Advanced …, 2023 - Wiley Online Library
Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing
chronic complication in diabetic patients, remain nonspecific. Hyperglycemia‐caused …

A whole‐course‐repair system based on neurogenesis‐angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing

Y Xiong, Z Lin, P Bu, T Yu, Y Endo, W Zhou… - Advanced …, 2023 - Wiley Online Library
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to
enhance neurogenesis and angiogenesis have appeared to be a promising direction …

Ultrasound-augmented multienzyme-like nanozyme hydrogel spray for promoting diabetic wound healing

L Shang, Y Yu, Y Jiang, X Liu, N Sui, D Yang, Z Zhu - ACS nano, 2023 - ACS Publications
Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower
blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the …

Engineered multifunctional zinc–organic framework-based aggregation-induced emission nanozyme for accelerating spinal cord injury recovery

J Zheng, T Chen, K Wang, C Peng, M Zhao, Q Xie… - ACS …, 2024 - ACS Publications
Functional recovery following a spinal cord injury (SCI) is challenging. Traditional drug
therapies focus on the suppression of immune responses; however, strategies for alleviating …

Cu-GA-coordination polymer nanozymes with triple enzymatic activity for wound disinfection and accelerated wound healing

H Tian, J Yan, W Zhang, H Li, S Jiang, H Qian, X Chen… - Acta Biomaterialia, 2023 - Elsevier
During the past few years, bacterial infection and oxidative stress have become important
issues for wound healing. However, the emergence of numerous drug-resistant superbugs …

An All‐in‐One “4A Hydrogel”: through First‐Aid Hemostatic, Antibacterial, Antioxidant, and Angiogenic to Promoting Infected Wound Healing

S Hu, Z Yang, Q Zhai, D Li, X Zhu, Q He, L Li… - Small, 2023 - Wiley Online Library
Currently used wound dressings are ineffective. Hence, there is a need to develop introduce
a high‐performance medicament with multiple functions including rapid hemostasis and …

[HTML][HTML] MOF-derived bimetallic nanozyme to catalyze ROS scavenging for protection of myocardial injury

K Xiang, H Wu, Y Liu, S Wang, X Li, B Yang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Rationale: Myocardial injury triggers intense oxidative stress, inflammatory response, and
cytokine release, which are essential for myocardial repair and remodeling. Excess reactive …

Nanozyme‐Cosmetic Contact Lenses for Ocular Surface Disease Prevention

Q Liu, S Zhao, Y Zhang, Q Fang, W Liu… - Advanced …, 2023 - Wiley Online Library
Efficiently balancing excess reactive oxygen species (ROS) caused by various factors on the
ocular surface is a promising strategy for preventing the development of ocular surface …