The relationship between depression and anxiety disorders has long been a matter of
controversy. The overlap of symptoms associated with these disorders makes diagnosis …

In this review, we describe the evolutionary process involved in the discovery of the selective
5-HT uptake inhibitor, fluoxetine, and summarize some of the large body of scientific …

Background Fluoxetine-induced liver damage is a cause of chronic liver disease. In the
present study the hepatoprotective effects of gallic acid against fluoxetine-induced liver …

Chronically administered antidepressant drugs, particularly selective serotonin (5-HT)
reuptake inhibitors (SSRIs), are clinically effective in the treatment of all anxiety disorders …

BackgroundThis study compared the efficacy and tolerability of paroxetine with placebo in
the treatment of panic disorder. MethodAfter three weeks of placebo, patients received 12 …

OBJECTIVE: This study was designed to determine the minimum paroxetine dose effective
for treating panic disorder. METHOD: Of 425 patients with DSM-III-R panic disorder with or …

The elevated T-maze (ETM) was developed to test the hypothesis that serotonin (5-HT)
plays an opposing role in the regulation of defensive behaviors associated with anxiety and …

The use of ethoexperimental techniques to elicit and maximize the full range of defensive
behaviors of rats and mice enables a very precise analysis of the effects of drugs on these …

Selective serotonin-reuptake inhibitors (SSRIs), including fluoxetine, sertraline, paroxetine,
fluvoxamine, and citalopram, represent an important advance in the pharmacotherapy of …

The selective serotonin reuptake inhibitors (SSRIs) are now being employed in the treatment
of the full spectrum of anxiety disorders. In comparative trials, the SSRIs are proving to be …