In the past two decades, antibody–drug conjugates have gained increasing attention
because they expand the therapeutic index when compared with that of traditional …

N-glycosylation of therapeutic antibodies starts as a co-translational step followed by a set of
post-translational modifications and is considered as one of the critical quality attributes …

Multi-dimensional liquid chromatography (MD-LC) continues to gain in popularity for
applications where conventional one-dimensional liquid chromatography is insufficient to …

Antibody–drug conjugates (ADCs) are biopharmaceuticals produced by chemically linking
small molecules (payloads) to antibodies that possess specific affinity for the target cell. The …

Fully automated analysis of multiple structural attributes of monoclonal antibodies (mAbs)
using three-dimensional liquid chromatography-mass spectrometry (3D-LC-MS) is …

Cation-exchange chromatography is a widely used approach to study charge heterogeneity
of monoclonal antibodies. Heterogeneity may arise both in vitro and in vivo because of the …

Abstract Characterization of post-translational modifications (PTMs) of therapeutic
antibodies is commonly performed by bottom-up approaches, involving sample preparation …

For the past few years, multidimensional liquid chromatography-mass spectrometry (LC-MS)
systems have been commonly used to characterize post-translational modifications (PTMs) …

Adeno-associated viruses (AAVs) are non-enveloped, single-stranded DNA viruses that
have recently emerged as an attractive vector for delivering genetic materials to hosts for …

An international study was conducted to evaluate the performance and reliability of an
online multi-dimensional (mD)-LC-MS/MS approach for the characterization of antibody …