Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Cellular senescence: from physiology to pathology

D Muñoz-Espín, M Serrano - Nature reviews Molecular cell biology, 2014 - nature.com
Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

[HTML][HTML] The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm

EL Chaikof, RL Dalman, MK Eskandari… - Journal of vascular …, 2018 - Elsevier
Background Decision-making related to the care of patients with an abdominal aortic
aneurysm (AAA) is complex. Aneurysms present with varying risks of rupture, and patient …

[HTML][HTML] The care of patients with an abdominal aortic aneurysm: the Society for Vascular Surgery practice guidelines

EL Chaikof, DC Brewster, RL Dalman… - Journal of vascular …, 2009 - Elsevier
The Clinical Practice Council of the Society for Vascular Surgery charged a writing
committee with the task of updating practice guidelines, initally published in 2003, for …

Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population

NK Itoga, KA Rothenberg, P Suarez, TV Ho… - Journal of vascular …, 2019 - Elsevier
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …

Single-cell transcriptomics reveals dynamic role of smooth muscle cells and enrichment of immune cell subsets in human abdominal aortic aneurysms

FM Davis, LC Tsoi, F Ma, R Wasikowski… - Annals of …, 2022 - journals.lww.com
Objective: To determine cell-specific gene expression profiles that contribute to development
of abdominal aortic aneurysms (AAAs). Background: AAAs represent the most common …

Abdominal aortic aneurysms and diabetes mellitus

K Pafili, I Gouni-Berthold, N Papanas… - Journal of Diabetes and …, 2015 - Elsevier
There is accumulating evidence that risk profiles differ between coronary artery disease and
abdominal aortic aneurysms (AAAs). However, diabetes mellitus (DM) appears to be …