There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Neuroblastoma (NB) is the most common and deadly solid tumour in children. Despite the
development of new treatment options for high-risk NB, over half of patients relapse and five …

Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is
largely unknown. Here we show that germline mutations in the anaplastic lymphoma kinase …

The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and
selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial …

Neuroblastoma in advanced stages is one of the most intractable paediatric cancers, even
with recent therapeutic advances. Neuroblastoma harbours a variety of genetic changes …

Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of
the most frequent solid tumours in childhood,. It usually occurs sporadically but familial …

Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system,
accounts for approximately 15% of all deaths due to childhood cancer. High-risk …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies …

Selective kinase inhibitors have had a substantial impact on the field of medical oncology.
Whereas these agents can elicit dramatic clinical responses in some settings, their activity is …