Cryptococcus gattii infections

SCA Chen, W Meyer, TC Sorrell - Clinical microbiology reviews, 2014 - Am Soc Microbiol
Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

Life Cycle of Cryptococcus neoformans

Y Zhao, J Lin, Y Fan, X Lin - Annual review of microbiology, 2019 - annualreviews.org
Cryptococcus neoformans is a ubiquitous environmental fungus and an opportunistic
pathogen that causes fatal cryptococcal meningitis. Advances in genomics, genetics, and …

Cryptococcus gattii: a resurgent fungal pathogen

V Chaturvedi, S Chaturvedi - Trends in microbiology, 2011 - cell.com
Cryptococcus gattii and Cryptococcus neoformans are causal agents of cryptococcosis,
which manifests as pneumonia and meningitis. C. gattii has recently received widespread …

The Trehalose Synthesis Pathway Is an Integral Part of the Virulence Composite for Cryptococcus gattii

P Ngamskulrungroj, U Himmelreich… - Infection and …, 2009 - Am Soc Microbiol
The trehalose pathway is essential for stress tolerance and virulence in fungi. We
investigated the importance of this pathway for virulence of the pathogenic yeast …

Calcineurin Governs Thermotolerance and Virulence of Cryptococcus gattii

YL Chen, VN Lehman, Y Lewit… - G3: Genes …, 2013 - academic.oup.com
The pathogenic yeast Cryptococcus gattii, which is causing an outbreak in the Pacific
Northwest region of North America, causes life-threatening pulmonary infections and …

Cryptococcus gattii Virulence Composite: Candidate Genes Revealed by Microarray Analysis of High and Less Virulent Vancouver Island Outbreak Strains

P Ngamskulrungroj, J Price, T Sorrell, JR Perfect… - PLoS …, 2011 - journals.plos.org
Human and animal cryptococcosis due to an unusual molecular type of Cryptococcus gattii
(VGII) emerged recently on Vancouver Island, Canada. Unlike C. neoformans, C. gattii …

Divergent Protein Kinase A isoforms co‐ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus

KK Fuller, DL Richie, X Feng, K Krishnan… - Molecular …, 2011 - Wiley Online Library
The genome of Aspergillus fumigatus encodes two isoforms of the catalytic subunit of the
cAMP‐dependent Protein Kinase (PKA). Although deletion of the class I isoform, pkaC1 …

Virulence of Cryptococcus sp. Biofilms In Vitro and In Vivo using Galleria mellonella as an Alternative Model

T Benaducci, JCO Sardi, NMS Lourencetti… - Frontiers in …, 2016 - frontiersin.org
Cryptococcus neoformans and C. gattii are fungal pathogens that are most commonly found
in infections of the central nervous system, which cause life-threatening …

Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence

C Roth, D Murray, A Scott, C Fu, AF Averette… - PLoS …, 2021 - journals.plos.org
Cryptococcal disease is estimated to affect nearly a quarter of a million people annually.
Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical …

Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis

TJC Sauters, C Roth, D Murray, S Sun… - PLoS …, 2023 - journals.plos.org
The “Amoeboid Predator-Fungal Animal Virulence Hypothesis” posits that interactions with
environmental phagocytes shape the evolution of virulence traits in fungal pathogens. In this …