Machine perfusion in liver transplantation
RX Sousa Da Silva, A Weber, P Dutkowski… - …, 2022 - Wiley Online Library
Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …
The role of mitochondria in liver ischemia‐reperfusion injury: from aspects of mitochondrial oxidative stress, mitochondrial fission, mitochondrial membrane permeable …
H Zhang, Q Yan, X Wang, X Chen… - Oxidative medicine …, 2021 - Wiley Online Library
Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …
Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation
Background Mitochondrial succinate accumulation has been suggested as key event for
ischemia reperfusion injury in mice. No specific data are however available on behavior of …
ischemia reperfusion injury in mice. No specific data are however available on behavior of …
Viability assessment in liver transplantation—what is the impact of dynamic organ preservation?
R Panconesi, M Flores Carvalho, M Mueller… - Biomedicines, 2021 - mdpi.com
Based on the continuous increase of donor risk, with a majority of organs classified as
marginal, quality assessment and prediction of liver function is of utmost importance. This is …
marginal, quality assessment and prediction of liver function is of utmost importance. This is …
Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome
AT Meszaros, J Hofmann, ML Buch, B Cardini… - …, 2022 - thelancet.com
Background Reliable biomarkers for organ quality assessment during normothermic
machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by …
machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by …
Endoplasmic reticulum stress and mitochondrial stress in drug-induced liver injury
S Pu, Y Pan, Q Zhang, T You, T Yue, Y Zhang, M Wang - Molecules, 2023 - mdpi.com
Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …
PEG35 and glutathione improve mitochondrial function and reduce oxidative stress in cold fatty liver graft preservation
RG Bardallo, I Company-Marin, E Folch-Puy… - Antioxidants, 2022 - mdpi.com
The need to meet the demand for transplants entails the use of steatotic livers, more
vulnerable to ischemia-reperfusion (IR) injury. Therefore, finding the optimal composition of …
vulnerable to ischemia-reperfusion (IR) injury. Therefore, finding the optimal composition of …
[HTML][HTML] Acteoside ameliorates hepatic ischemia-reperfusion injury via reversing the senescent fate of liver sinusoidal endothelial cells and restoring compromised …
K Jia, Y Zhang, R Luo, R Liu, Y Li, J Wu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Hepatic ischemia-reperfusion injury (HIRI), a common two-phase intersocietal reaction in
liver surgery, typically leading to sustained liver dysfunction. During this process, liver …
liver surgery, typically leading to sustained liver dysfunction. During this process, liver …
Polyethylene glycol 35 as a perfusate additive for mitochondrial and glycocalyx protection in HOPE liver preservation
A Panisello Rosello, R Teixeira da Silva… - International Journal of …, 2020 - mdpi.com
Organ transplantation is a multifactorial process in which proper graft preservation is a
mandatory step for the success of the transplantation. Hypothermic preservation of …
mandatory step for the success of the transplantation. Hypothermic preservation of …
TRPM2 non-selective cation channels in liver injury mediated by reactive oxygen species
ES Ali, GY Rychkov, GJ Barritt - Antioxidants, 2021 - mdpi.com
TRPM2 channels admit Ca2+ and Na+ across the plasma membrane and release Ca2+ and
Zn2+ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS) …
Zn2+ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS) …