Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

Ischemia‐reperfusion injury (IRI) has indeed been shown as a main complication of
hepatectomy, liver transplantation, trauma, and hypovolemic shock. A large number of …

Background Mitochondrial succinate accumulation has been suggested as key event for
ischemia reperfusion injury in mice. No specific data are however available on behavior of …

Based on the continuous increase of donor risk, with a majority of organs classified as
marginal, quality assessment and prediction of liver function is of utmost importance. This is …

Background Reliable biomarkers for organ quality assessment during normothermic
machine perfusion (NMP) are desired. ATP (adenosine triphosphate) production by …

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

The need to meet the demand for transplants entails the use of steatotic livers, more
vulnerable to ischemia-reperfusion (IR) injury. Therefore, finding the optimal composition of …

Hepatic ischemia-reperfusion injury (HIRI), a common two-phase intersocietal reaction in
liver surgery, typically leading to sustained liver dysfunction. During this process, liver …

Organ transplantation is a multifactorial process in which proper graft preservation is a
mandatory step for the success of the transplantation. Hypothermic preservation of …

TRPM2 channels admit Ca2+ and Na+ across the plasma membrane and release Ca2+ and
Zn2+ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS) …