Background Optimal antibacterial dosing is imperative for maximising clinical outcome.
Many factors can contribute to changes in the pharmacokinetics of antibacterials to the …

The determination of antibiotic potency against bacterial strains by assessment of their
minimum inhibitory concentration normally uses a standardized broth microdilution assay …

Background China launched a 3-year rectification scheme for the clinical use of antibiotics in
2011, and a specific scheme for carbapenem use in 2017. The aim of this study was to …

Pseudomonas aeruginosa bacteremia is associated with a high mortality rate, and
meropenem (MEPM) is commonly used to treat it. However, the relationship between the …

The study objective was to evaluate meropenem population pharmacokinetics and
pharmacodynamics in nonobese, obese, and morbidly obese patients. Forty adult patients …

Objectives To develop a population model to describe the pharmacokinetics (PK) of
intravenous meropenem in adult patients with severe burns and investigate potential …

Aims Beta‐lactam dose optimization in critical care is a current priority. We aimed to review
the pharmacokinetics (PK) of three commonly used beta‐lactams (amoxicillin±clavulanate …

The present study investigated the pharmacokinetics of meropenem and biapenem in bile
and estimated their pharmacodynamic target attainment at the site. Meropenem (0.5 g) or …

Objective The objective of this study was to develop a physiologically based
pharmacokinetic model for meropenem using a retrograde approach, which could serve as …

The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated
against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic …