We investigated the population pharmacokinetics (PK) of doripenem in Korean patients with
acute infections and determined an appropriate dosing regimen using a Monte Carlo …

The objectives of this study were to develop a population pharmacokinetic (PK) model of
meropenem, to simulate the percent time above minimum inhibitory concentration (% T> …

The pharmacokinetics of meropenem have not yet been examined in Japanese patients
receiving Continuous venovenous hemodialysis (CVVHD). The aim of this clinical …

Background The standard meropenem (MEPM) regimen allowed by insurance in Japan is
0.5 g two or three times a day. Differences in dosages and administration schedules in …

Purpose: To explore the plasma pharmacokinetics and heart distribution of Z-GP-EPI, a low
cardiotoxic prodrug of epirubicin (EPI). Methods: The drugs were administered to 20 rats (11 …

Introduction: With an increase in the incidence of Staphylococcus aureus infections in the
healthcare settings and in the community, trimethoprim/sulfamethoxazole (TMP/SMX) has …

A conventional nomogram, based on serum creatinine (sCr) and age, was developed in
order to determine the correct initial dosage regimen for meropenem (MEPM) infusions in …

Background: The most effective dosing strategy of meropenem for patients undergoing
continuous renal replacement therapy (CRRT) remains uncertain. This study aimed to …

Meropenem is a broad-spectrum antimicrobial frequently used for serious infections.
Understanding the pharmacokinetics of meropenem is crucial in optimizing the dosage …

A conventional nomogram, based on creatinine clearance (CCR), was developed to provide
an individualized, optimized, dosage regimen for the carbapenem antibacterial agents …