Therapeutic challenges in peripheral T-cell lymphoma

Y Luan, X Li, Y Luan, J Luo, Q Dong, S Ye, Y Li, Y Li… - Molecular Cancer, 2024 - Springer
Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of hematological
malignancies. Compared to our knowledge of B-cell tumors, our understanding of T-cell …

Novel target and treatment agents for natural killer/T-cell lymphoma

XP Tian, Y Cao, J Cai, YC Zhang, QH Zou… - Journal of Hematology & …, 2023 - Springer
The rapidly increasing use of high-throughput screening had produced a plethora of
expanding knowledge on the molecular basis of natural killer/T-cell lymphoma (NKTCL) …

Chidamide plus prednisone, etoposide, and thalidomide for untreated angioimmunoblastic T‐cell lymphoma in a Chinese population: a multicenter phase II trial

Y Wang, M Zhang, W Song, Q Cai… - American Journal of …, 2022 - Wiley Online Library
Angioimmunoblastic T‐cell lymphoma (AITL) is a common type of peripheral T‐cell
lymphoma (PTCL) with a poor prognosis, and an effective first‐line therapy is lacking …

Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment

D Li, H Liang, Y Wei, H Xiao, X Peng, W Pan - European Journal of …, 2023 - Elsevier
Histone demethylases play a critical role in gene transcription regulation and have been
implicated in cancer. Numerous reports have highlighted the overexpression of histone …

Epigenetics in Knee Osteoarthritis: A 2020–2023 Update Systematic Review

D Caldo, E Massarini, M Rucci, S Deaglio, R Ferracini - Life, 2024 - mdpi.com
Osteoarthritis is a leading cause of disability in the world. The scientific literature highlights
the critical importance of epigenetic regulatory effects, intertwined with biomechanical and …

Updates in pathobiological aspects of anaplastic large cell lymphoma

R Wu, MS Lim - Frontiers in Oncology, 2023 - frontiersin.org
Anaplastic large cell lymphomas (ALCL) encompass several distinct subtypes of mature T-
cell neoplasms that are unified by the expression of CD30 and anaplastic cytomorphology …

Differential diagnosis and identification of prognostic markers for peripheral T-cell lymphoma subtypes based on flow cytometry immunophenotype profiles

Q Pu, J Qiao, Y Liu, X Cao, R Tan, D Yan… - Frontiers in …, 2022 - frontiersin.org
We compared the differential expression of 15 markers in PTCL (Peripheral T-cell
lymphoma) subtypes and T-CUS (T-cell clones of uncertain significance), and summarized …

Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)

G Lu, S Jin, S Lin, Y Gong, L Zhang, J Yang, W Mou… - Clinical …, 2023 - Springer
Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with
generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy …

Enhancing anti-tumor immune responses through combination therapies: epigenetic drugs and immune checkpoint inhibitors

Y Liang, L Wang, P Ma, D Ju, M Zhao… - Frontiers in Immunology, 2023 - frontiersin.org
Epigenetic mechanisms are processes that affect gene expression and cellular functions
without involving changes in the DNA sequence. This abnormal or unstable expression of …

The role of epigenetic modifier mutations in peripheral T-cell lymphomas

AB Tigu, A Bancos - Current Issues in Molecular Biology, 2023 - mdpi.com
Peripheral T-cell lymphomas (PTCLs) are a group of diseases with a low incidence, high
degree of heterogeneity, and a dismal prognosis in most cases. Because of the low …