Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery

S Bernardo-Castro, JA Sousa, A Brás, C Cecília… - Frontiers in …, 2020 - frontiersin.org
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …

Neuroinflammation: friend and foe for ischemic stroke

RL Jayaraj, S Azimullah, R Beiram, FY Jalal… - Journal of …, 2019 - Springer
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Hemorrhagic transformation in ischemic stroke and the role of inflammation

E Spronk, G Sykes, S Falcione, D Munsterman… - Frontiers in …, 2021 - frontiersin.org
Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …

Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies

G Zhu, X Wang, L Chen, C Lenahan, Z Fu… - Frontiers in …, 2022 - frontiersin.org
Stroke is the second leading cause of global death and is characterized by high rates of
mortality and disability. Oxidative stress is accompanied by other pathological processes …

[HTML][HTML] Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective

T Tao, M Liu, M Chen, Y Luo, C Wang, T Xu… - Pharmacology & …, 2020 - Elsevier
There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell …

K Zhang, M Tu, W Gao, X Cai, F Song, Z Chen… - Nano …, 2019 - ACS Publications
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …

[HTML][HTML] The role of immune cells in post-stroke angiogenesis and neuronal remodeling: the known and the unknown

Y Ma, S Yang, Q He, D Zhang, J Chang - Frontiers in immunology, 2021 - frontiersin.org
Following a cerebral ischemic event, substantial alterations in both cellular and molecular
activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

P Klein, R Dingledine, E Aronica, C Bernard… - …, 2018 - Wiley Online Library
The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …