Background Leukocytes contribute to tissue damage after cerebral ischemia; however, the
mechanisms underlying this process are still unclear. This study investigates the temporal …

Regardless of the progress made in the pathogenesis of ischemic stroke, it remains a
leading cause of adult disability and death. To date, the most effective treatment for ischemic …

Objective Stroke is a kind of cerebrovascular disease with high mortality. TMAO has been
shown to aggravate stroke outcomes, but its mechanism remains unclear. Materials and …

Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and
pathophysiology. Several recent studies highlight the significance of inflammation in the …

Background Silent information regulator 1 (SIRT1) plays a beneficial role in cerebral
ischemic injury. Previous reports have demonstrated that transcutaneous electrical acupoint …

Background Neutrophils and lymphocytes mediate differential inflammatory responses after
ischemic stroke and have different effects on patients' clinical outcomes. Several studies …

Peripheral inflammation is known to trigger neuroinflammation and neurodegenerative
disease. However, the key components during the propagation of inflammation from the …

Ischemic stroke is one of the catastrophic neurological events that are being increasingly
recognized among Coronavirus Disease (COVID)-19 patients. The recent studies have …

Stroke is a cerebrovascular disorder that affects many people worldwide. In addition to the
well-established functions of astrocytes and microglia in stroke pathogenesis, pericytes also …

Inflammation in the central nervous system (CNS) contributes to disease pathologies by
disrupting the integrity of the blood–brain barrier (BBB). Tight junctions (TJ) are a key …