Context Excess mortality from heart disease is observed in patients with severe mental
disorder. This excess mortality may be rooted in adverse effects of pharmacological or …

The two-dimensional bipolar spectrum described here comprises a continuum of severity
from normal to psychotic and a continuum from depression, via three bipolar subgroups to …

The excess mortality observed in people with severe mental disorders (SMD) has not
improved over time and is not captured in estimates of disease burden. This study aimed to …

Bipolar disorder (BD) has traditionally been thought of as an episodic condition,
characterized by periods of hypomania/mania and depression. However, evidence is …

viii Preface disorders, the availability of effective medicinal treatments and partial
understanding of their neuropharmacology have strongly stimulated a generation of …

Background: Two clinical trials, prospectively designed for combined analysis, compared
placebo, lithium, and lamotrigine for treatment of bipolar I disorder in recently depressed or …

Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and
consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric …

The analysis of the functional correlates of “brain oscillations” has become an important
branch of neuroscience. Although research on the functional correlates of brain oscillation …

There is no data on the variation in the suicide risk over lifetime and on the suicide-
preventive effect of the long-term treatment of mood-disorder patients with antidepressants …

Objective To estimate the cardiovascular mortality among persons with bipolar disorder in
Sweden compared to the general population. Design Population register-based cohort study …