Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer
PA Watson, VK Arora, CL Sawyers - Nature Reviews Cancer, 2015 - nature.com
During the past 10 years, preclinical studies implicating sustained androgen receptor (AR)
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …
signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to …
The development of androgen-independent prostate cancer
BJ Feldman, D Feldman - Nature Reviews Cancer, 2001 - nature.com
The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …
Organoid cultures derived from patients with advanced prostate cancer
The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate
cancer has hampered progress in understanding disease pathogenesis and therapy …
cancer has hampered progress in understanding disease pathogenesis and therapy …
Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p
In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs;
however, pathological fractures frequently occur in PCa patients, and bone resorption is …
however, pathological fractures frequently occur in PCa patients, and bone resorption is …
[HTML][HTML] In vitro and in vivo model systems used in prostate cancer research
D Cunningham, Z You - Journal of biological methods, 2015 - ncbi.nlm.nih.gov
New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …
has been rising in other areas of the globe in recent years. In an effort to understanding the …
Molecular characterization of human prostate carcinoma cell lines
A van Bokhoven, M Varella‐Garcia, C Korch… - The …, 2003 - Wiley Online Library
BACKGROUND This study presents a comprehensive survey and characterization of
available prostate carcinoma cell lines, most of which have been widely used but are …
available prostate carcinoma cell lines, most of which have been widely used but are …
Osteoblasts in prostate cancer metastasis to bone
CJ Logothetis, SH Lin - Nature Reviews Cancer, 2005 - nature.com
Metastasis to bone is common in lung, kidney, breast and prostate cancers. However,
prostate cancer is unique in that bone is often the only clinically detectable site of …
prostate cancer is unique in that bone is often the only clinically detectable site of …
Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
XY Zhao, PJ Malloy, AV Krishnan, S Swami… - Nature medicine, 2000 - nature.com
The androgen receptor (AR) is involved in the development, growth and progression of
prostate cancer 1 (CaP). CaP often progresses from an androgen-dependent to an …
prostate cancer 1 (CaP). CaP often progresses from an androgen-dependent to an …
Cell lines used in prostate cancer research: a compendium of old and new lines—part 1
RE Sobel, MD Sadar - The Journal of urology, 2005 - Elsevier
PURPOSE:: This is part 1 of a 2-part review. Research into the molecular mechanisms
underlying the various aspects of prostate cancer (PCa) requires the use of in vivo and in …
underlying the various aspects of prostate cancer (PCa) requires the use of in vivo and in …
Functional and genetic characterization of three cell lines derived from a single tumor of an Opisthorchis viverrini-associated cholangiocarcinoma patient
B Sripa, W Seubwai, K Vaeteewoottacharn… - Human cell, 2020 - Springer
Three cholangiocarcinoma (CCA) cell line—formerly named, M156, M213 and M214 have
been intensively used with discrepancy of their tumor origins. They were assumed to be …
been intensively used with discrepancy of their tumor origins. They were assumed to be …