Chemokines and their receptors might be involved in the selection of specific organs by
metastatic cancer cells. For instance, the CXCR4-SDF-1α pair regulates adhesion and …

Background Androgens are required for both normal prostate development and prostate
carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to …

Clinical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing
landscape of PCa across racial populations has not been fully explored as a potential …

BACKGROUND Prostate carcinoma (PC) frequently metastasizes to bone, where it causes
significant morbidity and mortality. Stromal elements in the primary and metastatic target …

It is hypothesized that ligand-independent activation of the androgen receptor is one of the
mechanisms implicated in tumour progression. However, supportive evidence is limited to …

Simple Summary The molecular progression of prostate cancer is complex and elusive.
Biological research relies heavily on in vitro and in vivo models that can be used to examine …

Background Generation of suitable in vivo models is critical for understanding of processes
associated with development and progression of prostate cancer (CaP). Methods Lymph …

In prostate cancer, androgen blockade strategies are commonly used to treat osteoblastic
bone metastases. However, responses to these therapies are typically brief, and the …

BACKGROUND The acquisition of an androgen‐independent phenotype is the most serious
issue of prostate cancer treatment. Although several experimental cell models have been …

Aberrant protein glycosylation is known to be associated with the development of cancers.
The aberrant glycans are produced by the combined actions of changed glycosylation …