[HTML][HTML] The regulation and potential roles of m6A modifications in early embryonic development and immune tolerance at the maternal-fetal interface

H Liu, J Zheng, A Liao - Frontiers in Immunology, 2022 - frontiersin.org
The immune microenvironment at the maternal-fetal interface was determined by the
crosstalk between the trophoblast and maternal-derived cells, which dynamically changed …

[HTML][HTML] N6-methyladenosine modifications in maternal-fetal crosstalk and gestational diseases

S Wu, K Liu, B Zhou, S Wu - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
As a medium among pregnant women, environment and fetus, placenta owns powerful and
delicate epigenetic processes to regulate gene expression and maintain cellular …

[HTML][HTML] Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion

W Zhu, Y Gu, M Li, Z Zhang, J Liu, Y Mao, Q Zhu… - Clinical …, 2022 - Springer
Background Maternal air pollutants exposure is associated with a number of adverse
pregnancy outcomes, including recurrent spontaneous abortion (RSA). However, the …

[HTML][HTML] The N6-Methyladenosine Regulator ALKBH5 Mediated Stromal Cell–Macrophage Interaction via VEGF Signaling to Promote Recurrent Spontaneous …

Y Zhao, J Sun, L Jin - International Journal of Molecular Sciences, 2022 - mdpi.com
Successful conception requires the synchrony of multiple systems and organs.
Dysregulation of stromal cell–immune cell interactions has been proposed to be associated …

[HTML][HTML] Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner

Y Chen, X Liu, L Li, X He, F Zheng, Y Zhang, H Gao… - Molecular …, 2023 - Springer
Background With the increasing morbidity and mortality of preeclampsia (PE), it has posed a
huge challenge to public health. Previous studies have reported endoplasmic reticulum (ER) …

[HTML][HTML] RNA N6-methyladenosine modification in female reproductive biology and pathophysiology

E Huang, L Chen - Cell Communication and Signaling, 2023 - Springer
Gene expression and posttranscriptional regulation can be strongly influenced by epigenetic
modifications. N6-methyladenosine, the most extensive RNA modification, has been …

The m6A methyltransferase METTL3 promotes trophoblast cell invasion by regulating MYLK expression

J Zhao, H Ding, J Ding, X Shi, Y He, H Zhu, H Yuan… - Placenta, 2022 - Elsevier
Introduction The progression of placental diseases such as preeclampsia is closely related
to trophoblast dysfunction. Recent studies indicated the dysregulation of N6 …

[HTML][HTML] RNA m6A modifications in mammalian gametogenesis and pregnancy

X Sui, A Klungland, L Gao - Reproduction, 2023 - rep.bioscientifica.com
In brief RNA modifications play key roles in regulating various biological processes. This
article discusses and summarizes the recent advances of RNA m6A modifications related to …

[HTML][HTML] N6-methyladenosine modifications in the female reproductive system: roles in gonad development and diseases

H Mu, H Li, Y Liu, X Wang, Q Mei… - International journal of …, 2022 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is the most prevalent chemical modification in
eukaryotic messenger RNAs. By participating in various RNA-related bioprocesses …

[HTML][HTML] Associations between obesity, smoking behaviors, reproductive traits and spontaneous abortion: a univariable and multivariable Mendelian randomization …

Q Wang, F Liu, Y Tuo, L Ma, X Feng - Frontiers in Endocrinology, 2023 - frontiersin.org
Background The correlation between potential risk factors such as obesity (leg fat
percentage (left), arm fat percentage (left), waist circumference, body fat percentage, trunk …