[HTML][HTML] Can activation of NRF2 be a strategy against COVID-19?

A Cuadrado, M Pajares, C Benito… - Trends in …, 2020 - cell.com
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …

Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal

A Ayala, MF Muñoz, S Argüelles - Oxidative medicine and …, 2014 - Wiley Online Library
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …

Oxidative stress response and Nrf2 signaling in aging

H Zhang, KJA Davies, HJ Forman - Free Radical Biology and Medicine, 2015 - Elsevier
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

[HTML][HTML] Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D

N de Las Heras, VM Martín Giménez, L Ferder… - Antioxidants, 2020 - mdpi.com
Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …

[HTML][HTML] Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

DA Abed, M Goldstein, H Albanyan, H Jin… - Acta Pharmaceutica Sinica …, 2015 - Elsevier
Abstract The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that
protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction (PPI) has …

[HTML][HTML] The crosstalk between Nrf2 and inflammasomes

P Hennig, M Garstkiewicz, S Grossi… - International Journal of …, 2018 - mdpi.com
The Nrf2 (nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2)
transcription factor is a key player in cytoprotection and activated in stress conditions caused …

Implications of oxidative stress on viral pathogenesis

FC Camini, CC da Silva Caetano, LT Almeida… - Archives of …, 2017 - Springer
Reactive species are frequently formed after viral infections. Antioxidant defences, including
enzymatic and non-enzymatic components, protect against reactive species, but sometimes …

[HTML][HTML] Antioxidant and anti-inflammatory effects of coenzyme Q10 supplementation on infectious diseases

S Sifuentes-Franco, DC Sánchez-Macías… - Healthcare, 2022 - mdpi.com
With the appearance of new viruses and infectious diseases (ID) such as COVID-19 in 2019,
as well as the lack of specific pharmacological tools for the management of patients with …

[HTML][HTML] Effects of acute ammonia exposure and recovery on the antioxidant response and expression of genes in the Nrf2-Keap1 signalingápathway in the juvenile …

MJ Liu, HY Guo, KC Zhu, BS Liu, B Liu, L Guo… - Aquatic Toxicology, 2021 - Elsevier
Continuous exposure to high levels of ammonia can cause oxidative damage to fish tissues
and organs. To date, the mechanism by which juvenile golden pompano (Trachinotus …

[HTML][HTML] SARS-CoV-2 infection and oral health: therapeutic opportunities and challenges

CJ Coke, B Davison, N Fields, J Fletcher… - Journal of Clinical …, 2021 - mdpi.com
The novel corona virus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2),
and the disease it causes, COVID-19 (Coronavirus Disease-2019) have had multi-faceted …