The altered activation or overexpression of protein kinases (PKs) is a major subject of
research in oncology and their inhibition using small molecules, protein kinases inhibitors …

Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …

Gliomas are the most common type of brain cancer, and among them, glioblastoma
multiforme (GBM) is the most prevalent (about 60% of cases) and the most aggressive type …

The ability to undergo neoangiogenesis is a common feature with all cancers. Signaling
related to vascular endothelial growth factors (VEGF) and their receptors (VEGFR) plays a …

One of the biggest challenges in neuro-oncology is understanding the complexity of central
nervous system tumors, such as gliomas, in order to develop suitable therapeutics …

Background Malignant gliomas, the most common malignant brain tumors in adults,
represent a heterogeneous group of diseases with poor prognosis. Retroviruses can cause …

Glioblastoma is characterized by extensive vascularization and is highly resistant to current
therapy. Identification of drugs that target tumor directly and angiogenesis processes present …

Glioblastoma multiforme (GBM) is a highly aggressive malignant primary tumor in the central
nervous system. Despite extensive efforts in radiotherapy, chemotherapy, and neurosurgery …

Introduction Glioblastoma (GBM) is the most common primary brain tumor in adults. GBM
treatment options have been the same for the past 30 years and have only modestly …