A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …

[HTML][HTML] Role of dietary supplements and probiotics in modulating microbiota and bone health: the gut-bone axis

A de Sire, R de Sire, C Curci, F Castiglione, W Wahli - Cells, 2022 - mdpi.com
Osteoporosis is characterized by an alteration of bone microstructure with a decreased bone
mineral density, leading to the incidence of fragility fractures. Around 200 million people are …

The association of gut microbiota with osteoporosis is mediated by amino acid metabolism: multiomics in a large cohort

C Ling, Z Miao, M Xiao, H Zhou, Z Jiang… - The Journal of …, 2021 - academic.oup.com
Context Several small studies have suggested that the gut microbiome might influence
osteoporosis, but there is little evidence from human metabolomics studies to explain this …

[HTML][HTML] Exercise for osteoporosis: a literature review of pathology and mechanism

L Zhang, YL Zheng, R Wang, XQ Wang… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis (OP) is a disease that weakens bones and has a high morbidity rate
worldwide, which is prevalent among the elderly, particularly, women of postmenopausal …

Osteosarcopenia: A case of geroscience

B Kirk, A Al Saedi, G Duque - Aging Medicine, 2019 - Wiley Online Library
Many older persons lose their mobility and independence due to multiple diseases
occurring simultaneously. Geroscience is aimed at developing innovative approaches to …

[HTML][HTML] ac4C acetylation of RUNX2 catalyzed by NAT10 spurs osteogenesis of BMSCs and prevents ovariectomy-induced bone loss

W Yang, HY Li, YF Wu, RJ Mi, WZ Liu, X Shen… - … Therapy-Nucleic Acids, 2021 - cell.com
N-acetyltransferase 10 (NAT10) is the key enzyme for N4-acetylcytidine (ac4C) modification
of mRNA, which participates in various cellular processes and is related to many diseases …

[HTML][HTML] Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis

X Chen, X Zhu, A Wei, F Chen, Q Gao, K Lu, Q Jiang… - Bone research, 2021 - nature.com
Osteoporosis (OP) is a common skeletal disease involving low bone mineral density (BMD)
that often leads to fragility fracture, and its development is affected by multiple cellular …

[HTML][HTML] Identification of novel genes in aging osteoblasts using next-generation sequencing and bioinformatics

YJ Chen, WA Chang, MS Huang, CH Chen, KY Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
During the aging process, impaired osteoblastic function is one key factor of imbalanced
bone formation and age-related bone loss. The aim of this study is to explore the …

[HTML][HTML] Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis

X Chen, W Hua, X Huang, Y Chen, J Zhang… - Frontiers in …, 2020 - frontiersin.org
Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

[HTML][HTML] Prospect of stem cell therapy and regenerative medicine in osteoporosis

B Arjmand, M Sarvari, S Alavi-Moghadam… - Frontiers in …, 2020 - frontiersin.org
The field of cell therapy and regenerative medicine can hold the promise of restoring normal
tissues structure and function. Additionally, the main targets of stem cell-based therapies are …