Astrocytes are essential in maintaining normal brain functions such as blood brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …

Preclinical and clinical studies with various stem cells, their secretomes, and extracellular
vesicles (EVs) indicate their use as a promising strategy for the treatment of various …

Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …

Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …

Highlights•Reelin signaling is required for axonal targeting and refinement at the target
site.•Reelin signaling regulates dendritogenesis and spine formation in mature …

Background. The extracellular matrix of the PNS/CNS is unusual in that it is dominated by
glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties …

Previous studies have demonstrated that both CS and LiCl possess anti‐Alzheimer's
disease (AD) activities. We prepared chondroitin sulfate‐Li (CS‐Li) and investigated its …

The central nervous system/peripheral nervous system (CNS/PNS) extracellular matrix is a
dynamic and highly interactive space‐filling, cell‐supportive, matrix‐stabilising, hydrating …

The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal
conditions for neuronal function. Interactions between neurons and a specialized form of …

The extracellular matrix (ECM) is a significant component of the brain, constituting up to 20%
of the brain volume and perform multifarious functions during development, maturation and …