Abstract Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation
of in vivo cell-cell and cell-extracellular matrix interactions than conventional two …

The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Age-related complications such as neurodegenerative disorders are increasing and remain
cureless. The possibility of altering the progression or the development of these …

HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation
and glial activation that, together with the release of viral proteins, trigger a pathogenic …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Neurodegenerative diseases are a group of disorders characterized by progressive
degeneration of the structural and functional integrity of the central and peripheral nervous …

The high attrition rate of neuro-pharmaceuticals as they proceed to market necessitates the
development of clinically-relevant in vitro neural microphysiological systems that can be …

Many neurotoxicants affect energy metabolism in man, but currently available test methods
may still fail to predict mito-and neurotoxicity. We addressed this issue using LUHMES cells …

Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to
boost our understanding of the cellular mechanisms underlying brain pathophysiology …

Purpose Epidemiological and intervention studies have attempted to link the health effects of
a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in …