Immunotherapy has made remarkable strides in cancer therapy over the past decade.
However, such emerging therapy still suffers from the low response rates and immune …

Toll-like receptor (TLR) agonists demonstrate therapeutic promise as immunological
adjuvants for anticancer immunotherapy. To date, three TLR agonists have been approved …

Molecular imaging via afterglow luminescence minimizes tissue autofluorescence and
increases the signal-to-noise ratio. However, the induction of afterglow requires the prior …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

As the key defense molecules originally identified in Drosophila, Toll‐like receptor (TLR)
superfamily members play a fundamental role in detecting invading pathogens or damage …

Extramammary Paget's disease (EMPD) is a rare neoplasm that usually develops in
apocrine gland-bearing areas, such as the vulva, scrotum, and penis. EMPD may present …

Fish oil has been broadly reported as a potential supplement to ameliorate the severity of
some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries
across Europe and America and rapidly spread to more than 100 countries and regions. The …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …