Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240
loci that are associated with type 2 diabetes (T2D),; however, most of these loci have been …

Type 2 diabetes has rapidly developed into a major public health problem in south Asia
(defined here as Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka) in recent …

The epilepsies affect around 65 million people worldwide and have a substantial missing
heritability component. We report a genome-wide mega-analysis involving 15,212 …

To understand the genetics of type 2 diabetes in people of Japanese ancestry, we
conducted A meta-analysis of four genome-wide association studies (GWAS; 36,614 cases …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Psoriasis is an immune-mediated disease associated with skin and joint inflammation that
affects large proportions of populations worldwide. It is a heritable disease: individuals' …

Genome-wide association studies have implicated around 250 genomic regions in
predisposition to type 2 diabetes, with evidence for causal variants and genes emerging for …