We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

Objectives The purpose of this study was to examine the overlap in burnout and depression.
Method The sample comprised 1,386 schoolteachers (mean [M] age= 43; Myears taught …

Objectives. This 2013 update of the practice guidelines for the biological treatment of
unipolar depressive disorders was developed by an international Task Force of the World …

We aimed to characterize a large international cohort of outpatients with MDD within a
practical trial design, in order to identify clinically useful predictors of outcomes with three …

The current statement is a systematic review of the available data concerning the efficacy of
medication treatment of bipolar disorder (BP). A systematic MEDLINE search was made …

Second-generation antidepressants (SGADs) often cause neurological side effects (SEs).
This meta-analysis seeks to quantify the short-term rates of neurological SEs related to …

The Age of Psychopharmacology began with a brilliant rise in the 1950s, when for the first
time science entered the study of drugs that affect the brain and mind. But, esteemed …

Based on a careful literature search a review is presented of the history, background,
concepts and current use of comedication and polypharmacy in psychiatry. The pros and …

Novel 1-(1-benzoylpiperidin-4-yl) methanamine derivatives were designed as “biased
agonists” of serotonin 5-HT1A receptors. The compounds were tested in signal transduction …