With the development of society, traumatic bone defects caused by accidents, diseases and
surgeries have become common, eventually resulting in an increase in bone defects. The …

Objective The objective of the present paper was to review factors and conditions that are
associated with hard and soft‐tissue deficiencies at implant sites. Importance Hard‐and soft …

Recently, the genetic heterogeneity in osteogenesis imperfecta (OI), proposed in 1979 by
Sillence et al., has been confirmed with molecular genetic studies. At present, 17 genetic …

A review about design, manufacture, and mechanobiology of biodegradable scaffolds for
bone tissue engineering is given. First, fundamental aspects about bone tissue engineering …

The musculoskeletal system is significantly more complex than portrayed by traditional
reductionist approaches that have focused on and studied the components of this system …

Tissue engineering is a well-proven technique for the creation of functional alternatives for
regenerative medicine and plays a critical role in patient treatment. Several natural-origin …

The bone fracture cases have been increasing yearly, accompanied by the increased
number of patients experiencing non-union or delayed union after their bone fracture …

Bones are constantly remodeled throughout life to maintain robust structure and function.
Dysfunctional remodeling can result in pathological conditions such as osteoporosis (bone …

A new paradigm has emerged for osteogenesis imperfecta as a collagen-related disorder.
The more prevalent autosomal dominant forms of osteogenesis imperfecta are caused by …

Type I collagen (Col1) is the most abundant protein in mammals. Col1 contributes to 90% of
the total organic component of bone matrix. However, the precise cellular origin and …