Osteogenesis imperfecta (OI) is a heterogeneous genetic disorder characterized by bone
fragility and susceptibility to fractures after minimal trauma. After mutations in all known OI …

Osteogenesis imperfecta (OI) is characterized by bone fragility and fractures that may be
accompanied by bone deformity, dentinogenesis imperfecta, short stature, and shortened …

Zinc (Zn) is a vital element. It plays indispensable roles in multifarious cellular processes,
affecting the expression and activity of a variety of molecules, including transcription factors …

Bisphosphonates (BPs) have been widely, efficiently, and safely used for the treatment of
osteoporosis, malignant hypercalcemia, bone metastasis of solid cancers, and multiple …

Osteogenesis imperfecta (OI) is characterized by susceptibility to bone fractures, with a
severity ranging from subtle increase in fracture frequency to prenatal fractures. The first …

Osteogenesis imperfecta (OI) is a heterogenous group of genetic disorders of bone fragility.
OI type V is an autosomal-dominant disease characterized by calcification of the forearm …

Bone and cartilage and their disorders are addressed under the following headings:
functions of bone; normal and abnormal bone remodeling; osteopetrosis and osteoporosis; …

As one of the most important natural materials, cortical bone is a composite material
comprising assemblies of tropocollagen molecules and nanoscale hydroxyapatite mineral …

By the Shields classification, articulated over 30 years ago, inherited dentin defects are
divided into 5 types: 3 types of dentinogenesis imperfecta (DGI), and 2 types of dentin …

Publisher Summary Osteogenesis imperfecta (OI) or “brittle bone disease” is characterized
by reduced skeletal mass and bone fragility. OI has served as the paradigm for heritable …