Chronic pain and prescription opioid abuse are extremely prevalent in the United States and
worldwide. The consequences of opioid misuse can be life-threatening with significant …

Multiple pharmacotherapies are available for the treatment of fibromyalgia (FM), including
opioid analgesics. We postulate that the mechanism of action of traditional opioids predicts …

Importance Electronic health records are a potentially valuable source of information for
identifying patients with opioid use disorder (OUD). Objective To evaluate whether proxy …

Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of
the World Health Organization. However, their use can result in a number of unwanted side …

Background Nonmedical use of opioids has become increasingly problematic in recent
years with increases in overdoses, treatment admissions, and deaths. Use also appears to …

Opioid use disorder (OUD) is a major public health problem. High relapse rates and poor
treatment retention continue to pose major challenges in OUD treatment. Of the abused …

Opioid addiction can produce severe side effects including physical dependence and
withdrawal. Perturbations of the gut microbiome have recently been shown to alter opioid …

Background In light of the increased rates of Prescription Opioid (PO) misuse and
associated mortality in several developed countries in recent years, efforts have been made …

Objective. This study evaluated subcutaneous injections of tetrodotoxin (TTX) for the
treatment of moderate to severe, inadequately controlled cancer‐related pain. Methods …

All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain
stimulus”(the principal independent variable), which is delivered to an experimental subject …