Diabetes mellitus (DM) significantly increases the risk of heart disease, and DM-related
healthcare expenditure is predominantly for the management of cardiovascular …

The cardiovascular system is a complex and well-organized system in which glycosylation
plays a vital role. The heart and vascular wall cells are constituted by an array of specific …

Clinical and basic studies have documented that both hyperglycemia and insulin-resistance/
hyperinsulinemia not only constitute metabolic disorders contributing to cardiometabolic …

Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of
glucose, glucose metabolites, and other reducing sugars with different substrates, such as …

Protein glycosylation, which involves the attachment of carbohydrates to proteins, is one of
the most abundant protein co-translational and post-translational modifications. Advances in …

Although the protective effects of naringenin (Nar) on vascular smooth muscle cells (VSMCs)
have been confirmed, whether it has anti-proliferation and anti-migration effects in high …

Accumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic
contributor of diabetic vascular complications. We previously reported that elevated protein …

O-GlcNAcylation is a highly dynamic, reversible and atypical glycosylation that regulates the
activity, biological function, stability, sublocation and interaction of target proteins. O …

Objective We aimed to explore the role and possible mechanism of leptin in lower-extremity
artery calcification in patients with type 2 diabetes mellitus (T2DM). Methods We recruited 59 …

This review will provide an overview of what is currently known about mechanisms linking
poor glycaemic control with increased thrombotic risk. The leading causes of death in …