Cancer radiosensitizers
Radiotherapy (RT) is a mainstay treatment for many types of cancer, although it is still a
large challenge to enhance radiation damage to tumor tissue and reduce side effects to …
large challenge to enhance radiation damage to tumor tissue and reduce side effects to …
[HTML][HTML] Tumor hypoxia regulates immune escape/invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies
R Abou Khouzam, K Brodaczewska, A Filipiak… - Frontiers in …, 2021 - frontiersin.org
The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …
key role in molding tumor development by impacting the stromal and immune cell fractions …
[HTML][HTML] An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
SV Lindskrog, F Prip, P Lamy, A Taber… - Nature …, 2021 - nature.com
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …
by large biological heterogeneity with variable clinical outcomes. Here, we perform an …
[HTML][HTML] Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation …
L Zhou, J Jiang, Z Huang, P Jin, L Peng, M Luo… - Molecular cancer, 2022 - Springer
Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the
progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs …
progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs …
[HTML][HTML] Chemoradiotherapy in muscle-invasive bladder cancer: 10-yr follow-up of the phase 3 randomised controlled BC2001 trial
Background BC2001, the largest randomised trial of bladder-sparing treatment for muscle-
invasive bladder cancer (MIBC), demonstrated improvement in locoregional control by …
invasive bladder cancer (MIBC), demonstrated improvement in locoregional control by …
Impact of immune and stromal infiltration on outcomes following bladder-sparing trimodality therapy for muscle-invasive bladder cancer
Background Bladder-sparing trimodality therapy (TMT) is an alternative to radical cystectomy
(RC) for muscle-invasive bladder cancer (MIBC), and biomarkers to inform therapy selection …
(RC) for muscle-invasive bladder cancer (MIBC), and biomarkers to inform therapy selection …
[HTML][HTML] Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma …
Rationale: The current tumour-node-metastasis (TNM) staging system is insufficient for
precise treatment decision-making and accurate survival prediction for patients with stage I …
precise treatment decision-making and accurate survival prediction for patients with stage I …
[HTML][HTML] Development and validation of a 28-gene hypoxia-related prognostic signature for localized prostate cancer
Background Hypoxia is associated with a poor prognosis in prostate cancer. This work
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …
aimed to derive and validate a hypoxia-related mRNA signature for localized prostate …
[HTML][HTML] Evolution of urothelial bladder cancer in the context of molecular classifications
M Minoli, M Kiener, GN Thalmann… - International journal of …, 2020 - mdpi.com
Bladder cancer is a heterogeneous disease that is not depicted by current classification
systems. It was originally classified into non-muscle invasive and muscle invasive. However …
systems. It was originally classified into non-muscle invasive and muscle invasive. However …
[HTML][HTML] Hypoxia-related lncRNA correlates with prognosis and immune microenvironment in lower-grade glioma
Background Hypoxia-related genes are demonstrated to correlate with the prognosis of
various cancers. However, the role of hypoxia-related long non-coding RNAs (HRLs) in …
various cancers. However, the role of hypoxia-related long non-coding RNAs (HRLs) in …