The enzymatic complexes of the mitochondrial respiratory chain have been extensively
investigated in their structural and functional properties. A clear distinction is possible today …

Proper nucleosides availability is crucial for the proliferation of living entities (eukaryotic
cells, parasites, bacteria, and virus). Accordingly, the uses of inhibitors of the de novo …

The flavoenzyme dihydroorotate dehydrogenase catalyzes the stereoselective oxidation of
(S)-dihydroorotate to orotate in the fourth of the six conserved enzymatic reactions involved …

Malaria remains a globally prevalent infectious disease that leads to significant morbidity
and mortality. While there are a number of drugs approved for its treatment, drug resistance …

Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …

Human African trypanosomiasis (HAT) or 'sleeping sickness' is a neglected tropical disease
caused by the parasite Trypanosoma brucei. Novel models for funding pharmaceutical …

The combination of high-resolution LC–MS-based untargeted metabolomics with stable
isotope tracing provides a global overview of the cellular fate of precursor metabolites. This …

Introduction Visceral leishmaniasis (VL) is caused by Leishmania donovani. The purine and
pyrimidine pathways are essential for L. donovani. Simultaneously inhibiting multiple targets …

African sleeping sickness is endemic in sub-Saharan Africa where the WHO estimates that
60 million people are at risk for the disease. Human African trypanosomiasis (HAT) is 100 …

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo
biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to …