Leflunomide as an immunosuppressive drug is generally used in the treatment of
rheumatoid arthritis. It inhibits DHODH (dihydroorotate dehydrogenase), which is one of the …

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo
biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to …

African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed
pyrimidines from the host. However, uptake of pyrimidines in bloodstream form …

Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers,
autoimmune disorders and infectious diseases. This is also a cornerstone approach for …

Acetate: succinate CoA transferase (ASCT) is a mitochondrial enzyme that catalyzes the
production of acetate and succinyl-CoA, which is coupled to ATP production with succinyl …

Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in developing countries. Current treatment options …

Polyamine biosynthesis is a key drug target in African trypanosomes. The" resurrection drug"
eflornithine (difluoromethylornithine), which is used clinically to treat human African …

Dihydroorotate dehydrogenase (DHODH) is the fourth enzyme in the de novo pyrimidine
biosynthetic pathway and has been exploited as the target for therapy against proliferative …

Introduction: X-ray crystallography provides the majority of our structural biological
knowledge at a molecular level and, in terms of pharmaceutical design, is a valuable tool to …

Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and
chronic parasitic ailment that affects> 240 million people in 70 countries worldwide. It is the …