The successful treatment of cancer has significantly improved as a result of targeted therapy
and immunotherapy. However, during chemotherapy, cancer cells evolve and can acquire …

Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …

Chemodrug resistance is a major reason accounting for tumor recurrence. Given the
mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs …

Purpose To review and update the European LeukemiaNet (ELN) recommendations for the
management of chronic myeloid leukemia with imatinib and second-generation tyrosine …

Comparing independent high-throughput gene-expression experiments can generate
hypotheses about which gene-expression programs are shared between particular …

PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Motivation: Given the thousands of genes and the small number of samples, gene selection
has emerged as an important research problem in microarray data analysis. Support Vector …

Abstract The Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways are frequently
activated in leukemia and other hematopoietic disorders by upstream mutations in cytokine …

The intracellular redox homeostasis is a dynamic balancing system between the levels of
free radical species and antioxidant enzymes and small molecules at the core of cellular …